CD70 and non-Hodgkin lymphoma: Finally, the CD70-targeted ADC, MDX-1203/BMS-936561, conjugated to a DNA cross-linking alkylating agent has also been tested in the clinic (see clinical trial number NCT00944905) showing both evidence of efficacy and an acceptable safety profile at doses up to 8 mg/kg in patients suffering from NHL and clear cell RCC [31].