PCNA and neoplasm: The augmented inhibition of proliferation via apoptosis was verified by PCNA staining (Figure 4C and 4D) and TUNEL analysis (Figure 4E and 4F), and the enhanced anti-angiogenesis was confirmed by the alginate-encapsulated tumor cell assay and CD31 immunohistochemistry staining (Figure 5), whereas the improved immunological properties was verified by the increase of the infiltration of lymphocytes (Figure 6A and 6B) and in vitro CTL activity (Figure 6C).