ACTA1 and Hepatic fibrosis: In this study, we first demonstrate that casticin has an inhibitory effect on liver fibrosis in vitro and in vivo as evidenced by the alleviation of fibrosis-related injury accompanied by reductions in collagen deposition and the number of α-SMA-positive cells, as well as diminished expression of profibrogenic markers in mouse fibrotic liver induced by CCl4 or BDL.