MYC and neoplasm: Furthermore, in a Eμ-Myc transgenic mouse model in which constitutive overexpression of Myc in the B-cell compartment drives lymphomagenesis, it was reported that Myc overexpression results in 4E-BP1 hyperphosphorylation that was maintained during tumor progression and was required for cancer cell survival in Myc-dependent tumor initiation and maintenance [23].