SAHA's tumor-suppressive effect was replicated in a pseudohypoxic 786-O renal cell carcinoma mouse xenograft model characterized by constitutive HIF signaling (even in the absence of hypoxia) due to absent pVHL protein, which is necessary for ubiquitin-dependent degradation of HIF [68, 69]. The gene discussed is VHL; the disease is hereditary clear cell renal cell carcinoma.