BCL2 and neoplasm: Following DEN/PB-exposure Bcl-3Hep mice showed a significantly reduced mRNA expression of anti-apoptotic factors including Xiap (p < 0.001), Bcl2l1 (p < 0.05) and Bcl2 (p < 0.05) in the liver (Figure 2D) in parallel to increased rates of apoptosis in tumor tissue.