NFKB1 and neoplasm: Consistently, the NF-κB subunit p65 was significantly more phosphorylated in the liver of Bcl-3Hep mice compared to the wild type (p < 0.001 in tumor and p < 0.01 in surrounding liver tissue) (Figure 3D) and p65 activity was significantly elevated in Bcl-3Hep livers compared to wild type livers due to DEN/PB (Figure 3E).