To explore the mechanistic role of Bcl-3 during hepatocarcinogenesis, we used the two-stage diethylnitrosamine (DEN)/phenobarbital (PB) model of liver cancer in transgenic mice exhibiting a hepatocyte-specific overexpression of Bcl-3 (Bcl-3Hep) and corresponding littermate wild type controls. This evidence concerns the gene BCL3 and liver cancer.