The genotype “C/C” and “G/C-C/C” of rs3783546 in IL1A gene was associated with of RCC risk in Codominant(OR = 1.77, 95% CI=1.09-2.87, p = 0.04), dominant model (OR=1.41, 95%CI = 1.04-1.91, P= 0.025). This evidence concerns the gene IL1A and renal cell carcinoma.