The aim of the study was to analyze the diagnostic sensitivity of the c-KIT, DOG-1 and PKCθ expression in GIST and to perform a review of the 15 representative papers indexed in the Medline database (published between June 2004 and March 19, 2017) in the field of the supposed diagnostic value of the PKCθ [6–20]. This evidence concerns the gene KIT and gastrointestinal stromal tumor.