SMYD2 and cancer: Concordantly, treatment with siSMYD2 showed the significant growth suppressive effect on the four cancer cell lines compared with siNC (Figure 4D), implying that targeting SMYD2 could suppress SMYD2-mediated β-catenin methylation and induce the death of cancer cells harboring mutations in β-catenin or those in the β-catenin degradation machinery genes.