Taken together, these data indicated that gMDSC depletion enhanced CTLA-4 mAb induced CD8+ T-lymphocyte tumor infiltration and activation, DLN T-lymphocyte antigen-specific activation, and CD8-dependent tumor rejection with formation of immunologic memory in T-cell inflamed MOC1 but not non-T-cell inflamed MOC2 tumors. This evidence concerns the gene CTLA4 and neoplasm.