Our results, as summarized in Figure 6G, illustrate a key axis that contains DICER/miR-324-5p/ HMGXB3/WASF-2 in the epithelial cell cytoskeleton remodeling and dysregulated DICER/miR-324-5p/ HMGXB3/WASF-2 exacerbated gut inflammatory response and might lead to tumorigenesis of CRC. This evidence concerns the gene WASF2 and colorectal carcinoma.