On the contrary, on both DM1 and DM2 myotubes no insulin activation of ERK1 and ERK2 was observable during the experiment (ERK1, CTR vs DM2 p = 0.03; ERK2, CTR vs DM1 p = 0.05, CTR vs DM2 p = 0.01). This evidence concerns the gene MAPK1 and myotonic dystrophy type 1.