The western blot analysis of proteins of the insulin pathway showed that in TA the expression of p70S6K was similar in DM1 and in CTR samples, while Akt/PKB and ERK1/2 expression levels were significantly higher in DM1 than CTR (AKT/PKB, CTR vs DM1 p = 0.02; ERK1/2, CTR vs DM1 p = 0.01). This evidence concerns the gene RPS6KB1 and myotonic dystrophy type 1.