Western blot analysis of insulin pathway in skeletal muscle showed significant higher basal levels of phosphorylation of Akt/PKB (T308), p70S6K (T421/S424) and ERK1/2 (T202/Y204) in DM2 compared to CTR subjects, while the increase in protein phosphorylation was less evident in DM1 samples. The gene discussed is MAPK3; the disease is myotonic dystrophy type 2.