An evident increase of glucose uptake has been observed in CTR myotubes after stimulation with 10 nM insulin, on the contrary, in myotubes from both DM1 and DM2 subjects insulin showed a significant lower stimulatory effect (CTR vs DM1 p = 0.04; CTR vs DM2 p = 0.05). The gene discussed is INS; the disease is myotonic dystrophy type 1.