IRS1 and myotonic dystrophy type 1: Nevertheless, a significant lower Y896-IRS1 phosphorylation was observed at 5 and 15 minutes of insulin stimulation in both DM1 and DM2 as compared to controls (5 minutes: CTR vs DM1 p = 0.04, CTR vs DM2 p = 0.002; 15 minutes: CTR vs DM1 p = 0.01, CTR vs DM2 p = 0.03).