The ability of H2AX to suppress translocations has also been demonstrated in experiments with Eμ-c-Myc transgenic mice where a decrease in H2AX gene copy number lead to unbalanced clonal and non-clonal translocations in B cell lymphomas of Eμ-c-Myc+/− mice [46]. Here, MYC is linked to B-cell non-Hodgkin lymphoma.