SOD1 and hypertensive disorder: Moreover, we must also keep in mind the fact that the role of oxidative stress in priming hypertension in humans is still debated, even if oxidative stress biomarkers positively correlate with blood pressure in essential hypertension [32,41,78,108,119] and circulating SOD was recently found to be a marker of cardiovascular alterations in hypertensive and diabetic patients [164].