HSP90B2P and neoplasm: As most of the relevant oncoproteins in several tumor types, need elevated levels of HSP chaperonage for their folding, stabilization, aggregation, activation, function and proteolytic degradation [8,27], inhibition of HSPs and the chaperonage machinery offers the critical advantage of targeting multiple oncoproteins as well as different signaling pathways crucial for tumor progression [11,28].