Using short hairpin RNA or shRNA to knockdown Tid1, it has been shown that Tid1 can also negatively regulate the migration of cancer cells by depleting the interleukin-8 (IL-8) production, suggesting the fact that Tid1 could play an important role in suppressing tumor angiogenesis by inhibition of the angiogenic factor IL-8 [144]. Here, CXCL8 is linked to cancer.