Although most cancers are characterized by a lower HSP40 expression, cancer stem cells (CSCs) isolated from a population of renal cell carcinoma (RCC) showed considerably higher expression of DNAJB8 suggesting DNAJB8’s role in cancer initiation and its role as a specific antigen for CSCs making it an immunological target. The gene discussed is DNAJB8; the disease is hereditary clear cell renal cell carcinoma.