Moreover, both animal models and patient data show that these therapeutics are effective at inducing anti-cancer responses, and suggest that further clinical development of these therapies could greatly improve the lives of patients with GUCY2C-expressing cancers, including esophageal, gastric, pancreatic, and colorectal, establishing GUCY2C-targeted therapies as primary treatment modalities for these deadly diseases. Here, GUCY2C is linked to cancer.