Thus, we could not confirm a previous report indicating that simvastatin might protect MG-63 osteosarcoma cells from oxidative stress [59], which could be a result of an induction of the anti-apoptotic BCL2 apoptosis regulator by the runt related transcription factor 2 (RUNX2) in response to the treatment with hydrogen peroxide in that study [60]. The gene discussed is RUNX2; the disease is osteosarcoma.