One family of genes was disproportionately represented in the low‐risk donor including members of the Wnt and Cadherin signaling pathways [Protocadherin gamma‐A3 (PCDHGA3), Protocadherin beta‐8 (PCDHB8), Protocadherin gamma‐A6 (PCDHGA6), and Putative protocadherin beta‐18 (PCDHB18P)], implying that low‐risk donors may find it easier to form cell–cell junctions when compared with high‐risk RPE; thus, corroborating previously published data showing disrupted cell to cell junctions and induction of AMD‐associated pathological changes in light exposed RPE cells 45. This evidence concerns the gene PCDHB18P and age-related macular degeneration.