The high‐risk donors were specifically selected as having advanced AMD with unilateral wet AMD and reticular pseudo‐drüsen (a known high‐risk feature for both types of advanced AMD) in their fellow eyes (Supporting Information Fig. S1B, S1C′) and high‐risk SNP for CFH and low‐risk HTRA1 and ARMS2. The high‐risk CFH in combination with low‐risk HTRA1 polymorphism has been consistently associated with central drüsen formation in the older age group 32. This evidence concerns the gene HTRA1 and age-related macular degeneration.