INS and Hypoglycemia: The pre-specified primary analysis demonstrated that insulin degludec was non-inferior to insulin glargine in terms of cardiovascular events (HR 0.91, 95% CI 0.78, 1.06), and superior with regard to hypoglycaemia risk, with lower rates of both severe and nocturnal severe hypoglycaemia (by 40% and 53%, respectively; both p < 0.001), achieved at similar levels of glycaemic control as assessed by HbA1c [24].