The pre-specified analysis demonstrated that insulin degludec was non-inferior to insulin glargine in terms of cardiovascular events (HR 0.91, 95% CI 0.78, 1.06; p < 0.001 for non-inferiority), and superior with regard to hypoglycaemia risk, with a lower rate of both severe and nocturnal severe hypoglycaemia (by 40% and 53%, respectively; both p < 0.001) [15]. This evidence concerns the gene INS and Hypoglycemia.