CTLA4 and neoplasm: We have recently documented, in women with LLABCs undergoing NAC, that a significant reduction of both circulating and tumour-infiltrating Tregs (FOXP3+, CTLA-4+) and high levels of TILs and CD8+ T cells in the primary and ALN metastatic tumours were significantly associated with subsequent pCRs [13]; (Kaewkangsadan et al., 2016b submitted for publication).