Evidence that aberrant cardiac remodeling is attenuated by a variety of Nrf2 target genes such as SOD [95], HO-1 [96] and glutathione peroxidase (GPx) [97] has motivated investigation into a possible protective role of the Nrf2/Keap1/ARE pathway against cardiomyopathy in DM. Here, KEAP1 is linked to diabetes mellitus.