Regardless, mounting evidence of the importance of Nrf2 for vascular integrity and long-term endothelial function suggests that the Nrf2/Keap1/ARE pathway is influential in atherosclerotic resistance and may be a useful target for protection against coronary artery disease (CAD), peripheral vascular disease, and cerebrovascular disease in diabetic populations. This evidence concerns the gene KEAP1 and coronary artery disorder.