When WC, mFG, ft and SHBG, found to have a significant correlation with vitamin D in single factor analyses, and LH, DHEAS and HDL cholesterol, thought to be significant in regression analyses, were adjusted, 25-OH D levels were significantly low in all the patients with PCOS (B=-0.557 95%CI: -0.841- -0.274 and p<0.001) and the normal weight women with PCOS (B=-0.528 95%CI: -0.810- -0.245 and p<0.001) and the overweight women with PCOS (B=-0.788 95%CI: -1.160- -0.417 and p<0.001) compared to the controls. This evidence concerns the gene SULT2A1 and polycystic ovary syndrome.