Furthermore, the Hsp70 family members HSPA8 (Hsc70) and HSPA9 have lower expression in the SN (HSPA8/9) [55] and leukocytes (HSPA8) [56, 57] of PD patients relative to healthy controls, suggesting that chaperone levels and function may have a role in the pathogenesis of PD. The gene discussed is HSPA4; the disease is Parkinson disease.