A common pathway of induction of allergic airway inflammation is emerging in which allergens provoke the release of alarmins, such as IL-33, which stimulate lung-resident ILC2 to produce type 2 cytokines able to cause inflammation associated with allergic disease and to promote Th2 cell activation and the subsequent development of adaptive B cell responses and IgE production (Figure 1) (9). The gene discussed is IGHE; the disease is allergic disease.