We further confirmed that lncRNA TCONS_00088786 and TCONS_01496394 were regulated by TGF-β stimulation and also can influence the expression of some fibrosis-related genes through a feedback loop, which gave us a clue to further investigate the function and mechanism of the specific selected lncRNAs and develop a novel diagnostic method for renal fibrosis. The gene discussed is TGFB1; the disease is renal fibrosis.