The activated IS may also be an important factor in compromising blood brain barrier (BBB) in HTN, as specific cell types and their associated cytokines, such as IL17, which are known to be increased in HTN (Madhur et al., 2010; Amador et al., 2014), have been implicated in BBB damage (Kebir et al., 2007; Huppert et al., 2010). This evidence concerns the gene IL17A and hypertensive disorder.