C21 (0.03, 0.3 mg/kg/d IP) for 7 days post-MI: Improved MI-impaired cardiac function (echocardiography and cardiac catheterization); decreased scar (by MRI); Decreased inflammation (mRNA cytokines); and apoptosis (caspase 3, Fas ligand) in peri-infarct zone; C21 effects blocked by PD123319. This evidence concerns the gene CASP3 and myocardial infarction.