Freunds’ complete adjuvant induced arthritis assessment relies on the premise that high levels of proinflammatory cytokines, such as TNF-α and interleukin-1 (IL-1), lead to inflammation and bone erosion by inducing cartilage degeneration and osteoclast differentiation, resulting in the emergence of arthritis (Niki et al., 2004). Here, IL1B is linked to arthritic joint disease.