Recent studies also showed that a reduction of p75NTR expression ameliorates the cognitive deficits (Murphy et al., 2015) and increases cholinergic innervation in the dentate gyrus (Dokter et al., 2015), basolateral amygdala (Busch et al., 2017) and visual cortex (Von Bohlen und Halbach and Von Bohlen und Halbach, 2016); moreover, a small molecule ligand of p75NTR (LM11A-31) reverses cholinergic neurite dystrophy in Alzheimer’s Disease mouse models (Simmons et al., 2014). The gene discussed is NGFR; the disease is early-onset autosomal dominant Alzheimer disease.