Most attractively, heterozygous rare variants in TREM2 have been associated with a significant increase in the risk of AD emergence (Guerreiro et al., 2013), while TREM2 deficiency in an AD animal model, the 5xFAD, increased cerebral Aβ accumulation (Wang Y. et al., 2015). The gene discussed is TREM2; the disease is Alzheimer disease.