LGALS4 and Alzheimer disease: Additionally, we found that sleep fragmentation of AD flies was strongly increased over a period of 20 days of data acquisition when compared to both, elav-GAL4 (+80%; ***p < 0.001) and UAS-Aβ42/+ (+116.2%; ***p < 0.001) control group as well as in comparison to Oregon-R wild type strain (+158%; ***p < 0.001; Figures 5G–I).