LGALS4 and Alzheimer disease: Finelli et al. (2004) used the binary GAL4-UAS (Brand and Perrimon, 1993) system to achieve expression of human Aβ42 peptides in Drosophila. This approach to model AD in the fruit fly revealed dose-dependent phenotypes distinguishable by shortened life span and accumulations of insoluble Aβ42 peptides.