GAP43 and Alzheimer disease: In post-mortem AD brains, GAP-43 labeling indicated presynaptic neurite outgrowth in the hippocampal molecular layer, stratum polymorphous, the CA1 and prosubiculum with a high number of GAP-43-immunoreactive coiled fibers and dystrophic neurites closely apposed to plaques (Masliah et al., 1991).