Electrophysiological data obtained with the use of different models of epilepsy also suggest the insertion of GluA2-lacking calcium-permeable AMPARs in synapses of pyramidal cells after epileptic seizures (Prince et al., 2000; Sanchez et al., 2001; Rajasekaran et al., 2012; Joshi et al., 2017). This evidence concerns the gene GRIA2 and epilepsy.