GRIN2B and epilepsy: Some studies have shown that NMDARs with a high proportion of GluN2B subunits appear upregulated in epileptogenic tissue from patients with epilepsy and SE (Mathern et al., 1998; Loddenkemper et al., 2014), focal cortical dysplasia (Crino et al., 2001; Moddel et al., 2005; Finardi et al., 2006),and tuberous sclerosis complex (Talos et al., 2008).