This knockout model is especially relevant because the peripheral myelin protein 22 (PMP22) is closely connected with several hereditary human PNS neuropathies (Suter and Scherer, 2003; Fledrich et al., 2014), including Charcot-Marie-Tooth1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP). Here, PMP22 is linked to Charcot-Marie-Tooth disease type 1A.