The first which observed SOD1 associated with exosomes in ALS were Gomes et al. In their work, they have shown that wild type (SOD1wt) and mutant SOD1 (SOD1G93A) were in the supernatant medium from NSC-34 ALS cell model stably expressing hSOD1wt/G93A. Here, SOD1 is linked to amyotrophic lateral sclerosis.