They showed a new role of exosomal miR-155 and miR-21 in the communication between human monocytes and NB cells in the resistance to chemotherapy, by a unique exosomal miR-21/TLR8-NF-κB/exosomic miR-155/TERF1 signaling pathway (Challagundla et al., 2015). Here, TLR8 is linked to neuroblastoma.