In summary, a large amount of ROS is produced during cerebral ischemia and reperfusion, thereby promoting HMGB1 and IL-17A expression, and the up-regulation of IL-17A expression mediates the expression of a series of factors, which affect the p53 and PI3K/Akt signaling pathways and thereby promote apoptosis and aggravate injury. Here, HMGB1 is linked to Cerebral ischemia.