FXN and neuroblastoma: Mitochondrial failure promotes mitochondrial biogenesis in FRDA fibroblasts (García-Giménez et al., 2011), and increases the autophagy in SH-SY5Y human neuroblastoma cell model based on frataxin silencing (Bolinches-Amorós et al., 2014) and in conditional knock-out mouse (Simon et al., 2004).