PF-543, a selective, potent inhibitor of SphK1, attenuated epidermal growth factor-mediated cell growth and survival signaling through inhibition of AKT, ERK, and p38 MAP kinase pathways in LM2-4 cells, but not in the parental MDA-MB-231 human breast cancer cells [16]. The gene discussed is SPHK1; the disease is breast cancer.