MYC and neoplasm: Macrophage cluster tumor infiltration in Myc-CaP models exhibited a nominal but not significant (p > 0.05) increase indicating that changes in iron content of macrophages occurred within clusters rather than forming new deposits, while in TRAMP-C2 models macrophage infiltration was reduced in the iron(III) and CD68 clusters but only MRI measurements were associated with statistically significant reductions in these clusters (p < 0.01) with L1 chelation therapy (Fig. 5d,e).