In human, mutations in the SET domain of EZH2 are associated to aberrant epigenetic events both in DLBCL and follicular lymphoma44, 45, whereas this is the first evidence supporting a role of PcG proteins in dog and further investigation are necessary to study the mechanism of EZH2 in cDLBCL. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.