NOS2 and cancer: Among the 3 significantly enriched KEGG pathways, “Pathways in cancer” (KEGG ID 05200) showed highest significance (Bonferroni-adjusted p-value ≤ 0.001) and included 31 differentially methylated genes (Table S4) involved in key mechanisms such as control of apoptosis (p53, HRK), proliferation (PDGFA, FGFs, RARB, SHH, CCNE1, WNT, SHH) and angiogenesis (NOS2, SLC2A1).