ISG15 and neoplasm: We identified nineteen DMGRs with common methylation alterations among early stage tumor subtypes in comparison with normal tissues that were annotated to eleven genes via the 450 K annotation data set provided by Illumina: AGRN, C1orf170, FAM41C, FLJ39609, HES4, ISG15, KLHL17, NOC2L, PLEKNH1, SAMD11, and WASH5P (Table 2).