Figure 4E and F display the dose-response relation of nuclear NRF2, cytoplasmic NRF2, cytoplasmic KEAP1 and HO-1 upon treatment with FAEW or fluoxetine among human glioblastoma T98G and human neuroblastoma SH-SY5Y cell lines, respectively. The gene discussed is HMOX1; the disease is glioblastoma.