Intravenous albumin is used commonly in patients with AD/ACLF as a volume expander11, 12, 13 and has been proven to prevent and improve renal failure.14, 15 Many hepatologists believe it has additional properties,16 however, no multicenter evidence exists for these putative properties and critical-care studies have failed to establish a role.17 This evidence concerns the gene ALB and Alzheimer disease.