HOXB4 and leukemia: Long-term overexpression of HOXB4 in HSPCs skews commitment to different lineages and is associated with progression to leukemia [8] Oncogenesis was not observed in any mice, but lineage distribution of the graft within BM of IpLV-HOXB4 and IpLV-Angptl3 mice was altered significantly compared with controls (p < 0.01); differences observed in IdLV-treated mice were not statistically significant.