APOB and obesity due to melanocortin 4 receptor deficiency: All three acute-phase proteins correlated significantly and positively with measures of obesity (BMI, waist circumference, and fat mass), TAG, ApoB, glucose levels (FPG, 2hPG, and glucose AUC), alanine aminotransferase, and InsAUC0–30/GluAUC0–30, and negatively with the Matsuda ISI, disposition index, HDL cholesterol, and adiponectin level (Table 2).