We evaluated the associations of three acute-phase proteins, GlycA, IL-1RA, and hs-CRP, at baseline with insulin secretion, insulin sensitivity, and insulin resistance-related traits, and with disease outcomes, including incident type 2 diabetes, drug-treated hypertension, CVD events, and total mortality in initially nondiabetic men from the 6.8-year follow-up portion of the METSIM cohort. Here, INS is linked to hypertensive disorder.