The important findings from our study are as follows: (1) the GlycA levels were associated with a decrease in insulin secretion and increases in glucose levels (FPG, 2hPG, and glucose AUC) compared with IL-1RA and hs-CRP levels, which were associated with a decrease in insulin sensitivity, and increases in waist circumference and/or fat mass, and TAG; (2) GlycA was the best predictor of incident type 2 diabetes and CVD events among the three acute-phase proteins; and (3) combining the three markers improved the prediction of type 2 diabetes, CVD events, and total mortality. The gene discussed is INS; the disease is type 2 diabetes mellitus.