While tankyrase RNAi stabilizes AXIN and reduces β‐catenin‐dependent transcription in certain CRC cell lines (Huang et al.,2009; Callow et al.,2011), silencing of RNF146 fails to increase AXIN levels in HCT‐15 or SW480 CRC cells, both of which bear APC truncations, and does not inhibit Wnt/β‐catenin signalling in HCT‐15 cells (Callow et al.,2011). This evidence concerns the gene APC and colorectal carcinoma.