TNKS and neoplasm: Furthermore, overexpression of tankyrase in several tumour types has been reported (Matsutani et al.,2001; Gelmini et al.,2004, 2006, 2007; Shervington et al.,2007; Shebzukhov et al.,2008; Zhao et al.,2009; Gao et al.,2011; Tang et al.,2012; Busch et al.,2013) and may accentuate tankyrase's concentration‐dependent scaffolding functions, contributing to TNKSi resistance (Mariotti et al.,2016).