As expected, Wnt/β‐catenin signalling in CRC cells with oncogenic mutations in β‐catenin (LS174T, HCT116) or β‐catenin‐independent CRC cells (RKO) are not sensitive to tankyrase inhibition (Lau et al.,2013; Tanaka et al.,2017). This evidence concerns the gene TNKS and colorectal carcinoma.