CD8A and Sepsis: Surprisingly, sepsis impaired the recruitment of circulating cells to the site of skin TRM activation resulting in a 4.7-fold reduction in ear cellularity (compared to sham-treated mice), which was attributed to 5.6-, 3.1-, and 3.9-fold decreases in number of CD8+ and B cells (CD8-/B220+) and P14 cells in the ear, respectively (Fig 3B–3E).