Using the cecal ligation and puncture (CLP) experimental model of sepsis induction we previously determined that sepsis reduces the number of naïve CD4 and CD8 T cells and impairs primary T cell responses to a variety of acute (lymphocytic choriomeningitis virus (LCMV) Armstrong, Listeria monocytogenes, Candida albicans) and chronic (LCMV clone-13) infections [8,9,10,11]. The gene discussed is CD8A; the disease is infection.