IFNG and Sepsis: As administration of exogenous IFN-γ into barrier tissues can recapitulate TRM-anamnestic responses (e.g., vascular endothelium upregulation of adhesion molecules and chemokines that promote bystander activation), we first examined the extent to which sepsis affects the capacity of vascular endothelial cells to respond to exogenous IFN-γ [18].