Based on this observation, the incubation time of Gap27 is long enough to completely block the Cx43-based GJC mediated inflammatory response in present study, but whether Cxs-based and Panx1-based HCs are involved in the proliferation of T lymphocytes and the production of pro-inflammatory cytokines in hypertension is unknown. The gene discussed is PANX1; the disease is Hypertension.