To compare the HPgV effect on surrogate markers of HIV infection, we used the previously determined results shared by CIENI-INER [26,27] of HIV viral loads, CD4+ cell counts and CD4+/CD8+ ratio from 770 HIV-positive ART-naïve patients and HIV infection time from 303 HIV-positive ART-naïve patients. The gene discussed is CD8A; the disease is HIV infectious disease.